Innovative Probiotic Preparations Based on Bacteria of the Genus Bacillus: A Contribution to the Development of the Feed Base for Livestock Farming and Veterinary Medicine

The studies on the isolation, selection and study of strains of spore-forming bacteria with high antimicrobial and hydrolytic (protease, cellulolytic, xylanase, amylolytic) activity were conducted. Six most active cultures were selected, which were identified and deposited in the Belarusian collection of non-pathogenic microorganisms under the numbers: Bacillus velezensis BIM B-454, B. velezensis BIM B-497, B. velezensis BIM B-713, B. velezensis BIM B-844, B. velezensis BIM B-845, B. velezensis BIM B-1125. As a result of molecular genetic studies, the complete nucleotide sequence of the genome of B. velezensis BIM B-454 bacteria was obtained for the first time. The features of the chromosome organization of the strain were determined. The whole genome sequences have been annotated and deposited in the GenBank database under accession numbers CP082262.1-CP082265.1. Based on the studied bacterial strains, technologies have been developed for producing the probiotic feed additives Sporobact, Sporobact-K (B. velezensis BIM B-497 and B. velezensis BIM B-713) and the veterinary drugs Bacinil-K (B. velezensis BIM B-454), Emilin (B. velezensis BIM B-845), and Bacto-Health (B. velezensis BIM B-1125). These developments are characterized by a high degree of novelty, correspond to the global level of development of biological science, and make a significant contribution to the development of the “green economy”.

Natalia Sverchkova, and Emiliya Kalamiyets. Innovative Probiotic Preparations Based on Bacteria of the Genus Bacillus: A Contribution to the Development of the Feed Base for Livestock Farming and Veterinary Medicine. Journal of Agricultural Science and Technology A 16 (2026) 126-133, doi: 10.17265/2161-6256/2026.03.002

 

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